Five Steps for Structural Reform in Clinical Cancer Research

Reform of Clinical Research Regulations, Finally.

n engl j med 373;24 nejm.org december 10, 2015 2296 Another set of proposed changes aims to match the level of oversight to the level of risk the research poses to participants, by defining categories of research that are excluded from the Common Rule or are exempt from one or more of its requirements (e.g., IRB review). The excluded categories are activities that are deemed not to meet the rul...

First Steps to Judicial Reform

Five Steps for Crafting a Doctoral Research Proposal in Engineering Design

Doctoral students are required to prepare and defend a research proposal. In this paper, we present five steps for doctoral students to identify the questions that are worthy of investigation and thence to develop a research plan and proposal. Our method involves five steps, namely, Step 1: Frame the problem Step 2: Develop a research plan Step 3: Verification and validation Step 4: Proposal te...

Ethics in Clinical Research

There is no English abstract.

PI3K inhibitors for cancer treatment: five years of preclinical and clinical research after BEZ235.

Commentary on: Sauveur-Michel Maira, Fr ed eric Stauffer, Josef Brueggen, Pascal Furet, Christian Schnell, Christine Fritsch, Saskia Brachmann, Patrick Ch ene, Alain De Pover, Kevin Schoemaker, Doriano Fabbro, Daniela Gabriel, Marjo Simonen, Leon Murphy, Peter Finan, William Sellers, and Carlos García-Echeverría. Identification and characterization of NVP-BEZ235, a new orally available dual pho...